Immunologically Active Peptides


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Table of contents
  1. Biotechnology and Nanotechnology Risk Assessment: Minding and Managing the Potential Threats around Us.
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  4. Antigen Processing and Presentation.

The usual process of antigen presentation through the MHC I molecule is based on an interaction between the T-cell receptor and a peptide bound to the MHC class I molecule. The consequences of these polymorphisms are differential susceptibilities to infection and autoimmune diseases that may result from the high diversity of peptides that can bind to MHC class I in different individuals.

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Also, MHC class I polymorphisms make it virtually impossible to have a perfect tissue match between donor and recipient, and thus are responsible for graft rejection. MHC class II molecules bind to peptides that are derived from proteins degraded in the endocytic pathway.

Antigen presentation

Later, the CLIP is exchanged for an antigenic peptide derived from a protein degraded in the endosomal pathway. Different MHC class II alleles can be used as genetic markers for several autoimmune diseases, possibly owing to the peptides that they present. Register Log in.


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    Figure 1. The MHC class I antigen-presentation pathway.

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    Home Research Products. Research Products Bachem is specialized in the development and the manufacturing of biologically active peptides and complex organic molecules as active pharmaceutical ingredients APIs and as innovative biochemicals for research purposes.

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